Abstract
AbstractMonitoring of internal exposure to short-lived alpha-emitting radionuclides such as actinium-225 (225Ac), which are becoming increasingly important in nuclear medicine, plays an important role in the radiation protection of occupationally exposed persons. After having tested gamma spectrometry, liquid scintillation counting and alpha spectrometry for monitoring of internal exposure, the focus of the present study was on solid phase extraction of 225Ac from urine in combination with alpha spectrometry. The development of the method was based on recent findings from the literature on this topic. The method was used in a pilot phase to monitor internal exposure of four workers who were directly or indirectly involved in the manufacture and/or use of 225Ac. The monitoring protocol allowed a relatively short 24-hour urine sample analysis with excellent recovery of the internal standard, but it did not allow for a detection limit of less than 1 mBq nor a sufficient yield of 225Ac. Based on these results it is concluded that an in vitro excretion analysis alone is not appropriate for monitoring internal exposure to 225Ac. Instead, different radiation monitoring techniques have to be combined to ensure the radiation protection of employees.
Funder
Bundesamt für Strahlenschutz
Publisher
Springer Science and Business Media LLC
Reference20 articles.
1. AKI (2023) Monitoring in Radiological Emergencies – A Catalog of Requirements for Incorporation Monitoring of Individuals. (German: „Anforderungskatalog zu Inkorporationsüberwachungen von Personen bei radiologischen Notfällen) FS-2023-185-AKI (ISSN 1013–4506), Germany
2. Bajo S, Eikenberg J (1999) Electrodeposition of actinides for alpha-spectrometry. J Radioanal Nucl Chem 242:745–751. https://doi.org/10.1007/BF02347389
3. Cusnir R, Froidevaux P, Carbonez P, Straub M (2022) Solid-phase extraction of 225Ac using ion-imprinted resin and 243Am as a radioactive tracer for internal dosimetry and incorporation measurements. Anal Chim Acta 1191:339421. https://doi.org/10.1016/j.aca.2021.339421
4. DIN EN ISO/IEC 11929 (2021) Determination of the characteristic limits (decision threshold, detection limit and limits of the coverage interval) for measurements of ionizing radiation - Fundamentals and application - Part 1: Elementary applications (ISO 11929-1:2019); German version EN ISO 11929-1:2021
5. DIN 1319-1 (1995) Deutsches Institut für Normung 1319-1:1995-01. Fundamentals of metrology - Part 1: Basic terminology
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