Inhibition of the type 1 diabetes candidate gene PTPN2 aggravates TNF-α-induced human beta cell dysfunction and death-Reference-Cited by-同舟云学术

Inhibition of the type 1 diabetes candidate gene PTPN2 aggravates TNF-α-induced human beta cell dysfunction and death

Published:2023-03-29 Issue:8 Volume:66 Page:1544-1556
ISSN:0012-186X
Container-title:Diabetologia
language:en
Short-container-title:Diabetologia

Author:

Roca-Rivada Arturo^ORCID,Marín-Cañas Sandra^ORCID,Colli Maikel L.^ORCID,Vinci Chiara^ORCID,Sawatani Toshiaki^ORCID,Marselli Lorella^ORCID,Cnop Miriam^ORCID,Marchetti Piero^ORCID,Eizirik Decio L.^ORCID

Funder

European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie

INNODIA

NIH grant

JDRF

INNODIA HARVEST

Walloon Region SPW-EER

Welbio-FNRS

Leona M. and Harry B. Helmsley Charitable Trust

European Federation of Pharmaceutical Industries and Associations

Innovate2CureType1-Dutch Diabetes Research Foundation

Publisher

Springer Science and Business Media LLC

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://link.springer.com/content/pdf/10.1007/s00125-023-05908-5.pdf

Reference47 articles.

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2. Eizirik DL, Pasquali L, Cnop M (2020) Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure. Nat Rev Endocrinol 16(7):349–362. https://doi.org/10.1038/S41574-020-0355-7

3. Robertson CC, Inshaw JRJ, Onengut-Gumuscu S et al (2021) Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes. Nat Genet 53(7):962–971. https://doi.org/10.1038/s41588-021-00880-5

4. Santin I, Eizirik DL (2013) Candidate genes for type 1 diabetes modulate pancreatic islet inflammation and β-cell apoptosis. Diabetes Obes Metab 15(Suppl 3):71–81. https://doi.org/10.1111/DOM.12162

5. Marroquí L, Santin I, Dos Santos RS, Marselli L, Marchetti P, Eizirik DL (2014) BACH2, a candidate risk gene for type 1 diabetes, regulates apoptosis in pancreatic β-cells via JNK1 modulation and crosstalk with the candidate gene PTPN2. Diabetes 63(7):2516–2527. https://doi.org/10.2337/DB13-1443

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