Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes-Reference-Cited by-同舟云学术

Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes

Published:2021-06-14 Issue:7 Volume:53 Page:962-971
ISSN:1061-4036
Container-title:Nature Genetics
language:en
Short-container-title:Nat Genet

Author:

Robertson Catherine C.^ORCID,Inshaw Jamie R. J.,Onengut-Gumuscu Suna^ORCID,Chen Wei-Min,Santa Cruz David Flores,Yang Hanzhi,Cutler Antony J.^ORCID,Crouch Daniel J. M.,Farber Emily,Bridges S. Louis,Edberg Jeffrey C.,Kimberly Robert P.,Buckner Jane H.,Deloukas Panos^ORCID,Divers Jasmin,Dabelea Dana,Lawrence Jean M.^ORCID,Marcovina Santica,Shah Amy S.,Greenbaum Carla J.^ORCID,Atkinson Mark A.,Gregersen Peter K.^ORCID,Oksenberg Jorge R.,Pociot Flemming,Rewers Marian J.,Steck Andrea K.,Dunger David B.^ORCID,Wicker Linda S.^ORCID,Concannon Patrick,Todd John A.^ORCID,Rich Stephen S.^ORCID,

Funder

Juvenile Diabetes Research Foundation

Wellcome Trust

U.S. Department of Health & Human Services | NIH | U.S. National Library of Medicine

University of Virginia

U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases

U.S. Department of Health & Human Services | National Institutes of Health

U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

U.S. Department of Health & Human Services | Centers for Disease Control and Prevention

U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases

National Multiple Sclerosis Society

U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences

JDRF

Publisher

Springer Science and Business Media LLC

Subject

Genetics

Link

http://www.nature.com/articles/s41588-021-00880-5.pdf

Reference100 articles.

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2. Todd, J. A. et al. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat. Genet. 39, 857–864 (2007).

3. Onengut-Gumuscu, S. et al. Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers. Nat. Genet. 47, 381–386 (2015).

4. Inshaw, J. R. J., Walker, N. M., Wallace, C., Bottolo, L. & Todd, J. A. The chromosome 6q22.33 region is associated with age at diagnosis of type 1 diabetes and disease risk in those diagnosed under 5 years of age. Diabetologia 61, 147–157 (2018).

5. Fortune, M. D. et al. Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls. Nat. Genet. 47, 839–846 (2015).

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