Distinct subcellular localisation of intramyocellular lipids and reduced PKCε/PKCθ activity preserve muscle insulin sensitivity in exercise-trained mice-Reference-Cited by-同舟云学术

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Distinct subcellular localisation of intramyocellular lipids and reduced PKCε/PKCθ activity preserve muscle insulin sensitivity in exercise-trained mice

Published:2022-12-01 Issue:3 Volume:66 Page:567-578
ISSN:0012-186X
Container-title:Diabetologia
language:en
Short-container-title:Diabetologia

Author:

Gaspar Rafael C.,Lyu Kun,Hubbard Brandon T.,Leitner Brooks P.,Luukkonen Panu K.,Hirabara Sandro M.,Sakuma Ikki,Nasiri Ali,Zhang Dongyan,Kahn Mario,Cline Gary W.,Pauli José Rodrigo,Perry Rachel J.,Petersen Kitt F.,Shulman Gerald I.

Funder

Center for Integrated Healthcare, U.S. Department of Veterans Affairs

Fundação de Amparo à Pesquisa do Estado de São Paulo

National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

Springer Science and Business Media LLC

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://link.springer.com/content/pdf/10.1007/s00125-022-05838-8.pdf

Reference40 articles.

1. Petersen MC, Shulman GI (2018) Mechanisms of insulin action and insulin resistance. Physiol Rev 98(4):2133–2223. https://doi.org/10.1152/physrev.00063.2017

2. Laurens C, Moro C (2016) Intramyocellular fat storage in metabolic diseases. Horm Mol Biol Clin Investig 26(1):43–52. https://doi.org/10.1515/hmbci-2015-0045

3. Shulman GI (2014) Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease. N Engl J Med 371(12):1131–1141. https://doi.org/10.1056/nejmra1011035

4. Weiss R, Dufour S, Taksali SE et al (2003) Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning. Lancet 362(9388):951–957. https://doi.org/10.1016/S0140-6736(03)14364-4

5. Krssak M, Falk Petersen K, Dresner A et al (1999) Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1 H NMR spectroscopy study. Diabetologia 42(1):113–116. https://doi.org/10.1007/s001250051123

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