<i>O</i>-linked <i>N</i>-acetylglucosamine modification is essential for physiological adipose expansion induced by high-fat feeding-Reference-Cited by-同舟云学术

O-linked N-acetylglucosamine modification is essential for physiological adipose expansion induced by high-fat feeding

Published:2023-07-01 Issue:1 Volume:325 Page:E46-E61
ISSN:0193-1849
Container-title:American Journal of Physiology-Endocrinology and Metabolism
language:en
Short-container-title:American Journal of Physiology-Endocrinology and Metabolism

Author:

Nakamoto Akiko¹,Ohashi Natsuko¹²,Sugawara Lucia¹,Morino Katsutaro¹³^ORCID,Ida Shogo¹^ORCID,Perry Rachel J.⁴⁵^ORCID,Sakuma Ikki⁴⁵,Yanagimachi Tsuyoshi¹,Fujita Yukihiro¹^ORCID,Ugi Satoshi¹^ORCID,Kume Shinji¹,Shulman Gerald I.⁴⁵^ORCID,Maegawa Hiroshi¹

Affiliation:

1. Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan

2. Department of Stem Cell Biology and Regenerative Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan

3. Institutional Research Office, Shiga University of Medical Science, Otsu, Shiga, Japan

4. Department of Medicine (Endocrinology), Yale University School of Medicine, New Haven, Connecticut, United States

5. Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, United States

Abstract

We evaluated the role of O-GlcNAcylation in adipose tissue in diet-induced obesity using adipose tissue-specific Ogt knockout mice. We found that O-GlcNAcylation in adipose tissue is essential for healthy fat expansion and that Ogt-FKO mice exhibit severe fibrosis upon long-term overnutrition. O-GlcNAcylation in adipose tissue may regulate de novo lipogenesis and free fatty acid efflux to the degree of overnutrition. We believe that these results provide new insights into adipose tissue physiology and obesity research.

Funder

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Japan Diabetes Society

Japan Foundation for Applied Enzymology

MEXT | Japan Society for the Promotion of Science

Shiga University of Medical Science

Publisher

American Physiological Society

Subject

Physiology (medical),Physiology,Endocrinology, Diabetes and Metabolism

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpendo.00263.2022