Metformin increases fasting glucose clearance and endogenous glucose production in non-diabetic individuals
Author:
Funder
University of Dundee
Publisher
Springer Science and Business Media LLC
Subject
Endocrinology, Diabetes and Metabolism,Internal Medicine
Link
http://link.springer.com/content/pdf/10.1007/s00125-019-05042-1.pdf
Reference12 articles.
1. Hunter RW, Hughey CC, Lantier L et al (2018) Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase. Nat Med 24(9):1395–1406. https://doi.org/10.1038/s41591-018-0159-7
2. Miller RA, Birnbaum MJ (2010) An energetic tale of AMPK-independent effects of metformin. J Clin Invest 120(7):2267–2270. https://doi.org/10.1172/JCI43661
3. DeFonzo RA, Barzilai NIR, Simonson DC (1991) Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects. J Clin Endocrinol Metab 73(6):1294–1301. https://doi.org/10.1210/jcem-73-6-1294
4. McCreight LJ, Bailey CJ, Pearson ER (2016) Metformin and the gastrointestinal tract. Diabetologia 59(3):426–435. https://doi.org/10.1007/s00125-015-3844-9
5. Rena G, Hardie DG, Pearson ER (2017) The mechanisms of action of metformin. Diabetologia 60(9):1577–1585. https://doi.org/10.1007/s00125-017-4342-z
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