The transcription factor STAT6 plays a critical role in promoting beta cell viability and is depleted in islets of individuals with type 1 diabetes
Author:
Funder
Diabetes UK
Publisher
Springer Science and Business Media LLC
Subject
Endocrinology, Diabetes and Metabolism,Internal Medicine
Link
http://link.springer.com/article/10.1007/s00125-018-4750-8/fulltext.html
Reference43 articles.
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2. Campbell-Thompson ML, Atkinson MA, Butler AE et al (2013) The diagnosis of insulitis in human type 1 diabetes. Diabetologia 56(11):2541–2543. https://doi.org/10.1007/s00125-013-3043-5
3. Babon JB, DeNicola ME, Blodgett DM et al (2016) Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nat Med 22(12):1482–1487. https://doi.org/10.1038/nm.4203
4. Leete P, Willcox A, Krogvold L et al (2016) Differential insulitic profiles determine the extent of β-cell destruction and the age at onset of type 1 diabetes. Diabetes 65(5):1362–1369. https://doi.org/10.2337/db15-1615
5. Thomas HE, Kay TW (2011) Intracellular pathways of pancreatic β-cell apoptosis in type 1 diabetes. Diabetes Metab Res Rev 27(8):790–796. https://doi.org/10.1002/dmrr.1253
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