Analytical and pharmacological consequences of the in vivo deamidation of trastuzumab and pertuzumab-Reference-Cited by-同舟云学术

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Analytical and pharmacological consequences of the in vivo deamidation of trastuzumab and pertuzumab

Published:2022-01-10 Issue:4 Volume:414 Page:1513-1524
ISSN:1618-2642
Container-title:Analytical and Bioanalytical Chemistry
language:en
Short-container-title:Anal Bioanal Chem

Author:

Bults Peter,van der Voort Anna,Meijer Coby,Sonke Gabe S.,Bischoff Rainer,van de Merbel Nico C.

Publisher

Springer Science and Business Media LLC

Subject

Biochemistry,Analytical Chemistry

Link

https://link.springer.com/content/pdf/10.1007/s00216-021-03756-z.pdf

Reference25 articles.

1. Schadt S, Hauri S, Lopes F, Edelmann MR, Staack RF, Villasenor R, Kettenberger H, Roth AB, Schuler F, Richter WF, Funk C. Are biotransformation studies of therapeutic proteins needed? Scientific considerations and technical challenges. Drug Metab Disp. 2019;47:1443–56.

2. Li Y, Monine M, Huang Y, Swann P, Nestorov I, Lyubarskaya Y. Quantitation and pharmacokinetic modeling of therapeutic antibody quality attributes in human studies. mAbs. 2015;8:1079–87.

3. Kellie JF, Karlinsey MZ. Review of approaches and examples for monitoring biotransformation in protein and peptide therapeutics by MS. Bioanalysis. 2018;10:1877–90.

4. Tumey LN, Rago B, Han X. In vivo biotransformations of antibody-drug conjugates. Bioanalysis. 2015;7:1649–64.

5. Liu YD, Goetze AM, Bass RB, Flynn GC. N-terminal glutamate to pyroglutamate conversion in vivo for human IgG2 antibodies. J Biol Chem. 2011;286:11211–7.

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