Author:
Casquel Rafael,Holgado Miguel,Laguna María F.,Hernández Ana L.,Santamaría Beatriz,Lavín Álvaro,Luca Tramarin ,Herreros Pedro
Abstract
AbstractIn this work, we review the technology of vertically interrogated optical biosensors from the point of view of engineering. Vertical sensors present several advantages in the fabrication processes and in the light coupling systems, compared with other interferometric sensors. Four different interrelated aspects of the design are identified and described: sensing cell design, optical techniques used in the interrogation, fabrication processes, fluidics, and biofunctionalization of the sensing surface. The designer of a vertical sensor should decide carefully which solution to adopt on each aspect prior to finally integrating all the components in a single platform. Complexity, cost, and reliability of this platform will be determined by the decisions taken on each of the design process. We focus on the research and experience acquired by our group during last years in the field of optical biosensors.
Funder
Spanish RD plan under project HERON
Publisher
Springer Science and Business Media LLC
Subject
Biochemistry,Analytical Chemistry
Cited by
13 articles.
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