Author:
Lord Rachel N.,Utomi Victor,Oxborough David L.,Curry Bryony A.,Brown Megan,George Keith P.
Abstract
Abstract
Background
The cardiac consequences of undertaking endurance exercise are the topic of
recent debate. The purpose of this review is to provide an update on a growing
body of literature, focusing on left ventricular (LV) function following
prolonged endurance exercise over 2 h in duration which have employed novel
techniques, including myocardial speckle tracking, to provide a more
comprehensive global and regional assessment of LV mechanics.
Methods
Prospective studies were filtered independently following a pre-set criteria,
resulting in the inclusion of 27 studies in the analyses. A random-effects
meta-analysis was used to determine the weighted mean difference and 95%
confidence intervals (CI) of LV functional and mechanical data from
pre-to-post-exercise. Narrative commentary was also provided where volume of
available evidence precluded meta-analysis.
Results
A significant overall reduction in LV longitudinal strain (Ɛ) n = 22
(− 18 ± 1 to − 17 ± 1%; effect size (d) − 9:
− 1 to − 0.5%), strain rate n = 10 (SR;d − 0.9: − 0.1.3 to − 0.5 l/s) and twistn = 5 (11.9 ± 2.2 to 8.7 ± 2.2°,d − 1: − 1.6 to − 0.3°) was observed
following strenuous endurance exercise (range 120–1740 min) (P < 0.01). A smaller number of studies
(n = 4) also reported a non-significant
reduction in global circumferential and radial Ɛ (P > 0.05).
Conclusion
The meta-analysis and narrative commentary demonstrated that a reduction in LV
function and mechanics is evident following prolonged endurance exercise. The
mechanism(s) responsible for these changes are complex and likely
multi-factorial in nature and may be linked to right and left ventricular
interaction.
Publisher
Springer Science and Business Media LLC
Subject
Physiology (medical),Public Health, Environmental and Occupational Health,Orthopedics and Sports Medicine,General Medicine,Public Health, Environmental and Occupational Health,Physiology
Cited by
23 articles.
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