Lifelong physiology of a former marathon world-record holder: the pros and cons of extreme cardiac remodeling-Reference-Cited by-同舟云学术

Lifelong physiology of a former marathon world-record holder: the pros and cons of extreme cardiac remodeling

Published:2024-09-01 Issue:3 Volume:137 Page:461-472
ISSN:8750-7587
Container-title:Journal of Applied Physiology
language:en
Short-container-title:Journal of Applied Physiology

Author:

Foulkes Stephen J.¹²^ORCID,Haykowsky Mark J.²^ORCID,Kistler Peter M.³,McConell Glenn K.⁴,Trappe Scott⁵^ORCID,Hargreaves Mark⁶^ORCID,Costill David L.⁵,La Gerche Andre¹⁷^ORCID

Affiliation:

1. Heart, Exercise and Research Trials (HEART) Lab, St Vincent’s Institute, Fitzroy, Victoria, Australia

2. Integrated Cardiovascular and Exercise Physiology and Rehabilitation (iCARE) Lab, College of Health Sciences, University of Alberta, Edmonton, Alberta, Canada

3. Department of Cardiology, The Alfred Hospital, Melbourne, Victoria, Australia

4. Institute for Health and Sport, Victoria University, Footscray, Victoria, Australia

5. Human Performance Laboratory, Ball State University, Muncie, Indiana, United States

6. Department of Physiology, University of Melbourne, Melbourne, Victoria, Australia

7. HEART Lab, Victor Chang Cardiovascular Research Institute, Darlinghurst, NSW, Australia

Abstract

This life study of a 77-yr-old former world champion marathon runner exemplifies the impact of lifelong high-volume endurance exercise on functional capacity (V̇o2max equivalent to a 20- to 29-yr-old), partly due to extreme ventricular remodeling that facilitates a large cardiac output during exercise despite reduced maximal heart rate. Although it is possible that this extreme remodeling may contribute to developing atrial fibrillation, the net benefits of extreme exercise throughout this athlete’s lifespan favor increased health span and expected longevity.

Funder

DHAC | National Health and Medical Research Council

HHS | NIH | National Institute on Aging

Publisher

American Physiological Society

Link

https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00070.2024

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