Effect of CYP2C19, UGT1A8, and UGT2B7 on valproic acid clearance in children with epilepsy: a population pharmacokinetic model
Author:
Funder
National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Pharmacology,General Medicine
Link
http://link.springer.com/article/10.1007/s00228-018-2440-6/fulltext.html
Reference47 articles.
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2. Loscher W (2002) Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy. CNS Drugs 16:669–694
3. Budi T, Toth K, Nagy A et al (2015) Clinical significance of CYP2C9-status guided valproic acid therapy in children. Epilepsia 56:849–855. https://doi.org/10.1111/epi.13011
4. Marahatta A, Bhandary B, Jeong SK, Kim HR, Chae HJ (2014) Soybean greatly reduces valproic acid plasma concentrations: a food-drug interaction study. Sci Rep 4:4362. https://doi.org/10.1038/srep04362
5. Lin WW, Jiao Z, Wang CL, Wang HY, Ma CL, Huang PF, Guo XZ, Liu YW (2015) Population pharmacokinetics of valproic acid in adult Chinese epileptic patients and its application in an individualized dosage regimen. Ther Drug Monit 37:76–83. https://doi.org/10.1097/ftd.0000000000000100
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