Near-fatal tramadol cardiotoxicity in a CYP2D6 ultrarapid metabolizer-Reference-Cited by-同舟云学术

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Near-fatal tramadol cardiotoxicity in a CYP2D6 ultrarapid metabolizer

Published:2011-06-21 Issue:8 Volume:67 Page:855-858
ISSN:0031-6970
Container-title:European Journal of Clinical Pharmacology
language:en
Short-container-title:Eur J Clin Pharmacol

Author:

Elkalioubie Ahmed,Allorge Delphine,Robriquet Laurent,Wiart Jean-François,Garat Anne,Broly Franck,Fourrier François

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,General Medicine

Link

http://link.springer.com/content/pdf/10.1007/s00228-011-1080-x.pdf

Reference20 articles.

1. Grond S, Sablotzki A (2004) Clinical pharmacology of tramadol. Clin Pharmacokinet 43:879–923

2. Paar WD, Poche S, Gerloff J, Dengler HJ (1997) Polymorphic CYP2D6 mediates O-demethylation of the opioid analgesic tramadol. Eur J Clin Pharmacol 53:235–239

3. Pedersen RS, Damkier P, Brøsen K (2006) Enantioselective pharmacokinetics of tramadol in CYP2D6 extensive and poor metabolizers. Eur J Clin Pharmacol 62:513–521

4. Garcia-Quetglas E, Azanza JR, Sadaba B, Munoz MJ, Gil I, Campanero MA (2007) Pharmacokinetics of tramadol enantiomers and their respective phase I metabolites in relation to CYP2D6 phenotype. Pharmacol Res 55:122–130

5. Stamer UM, Musshoff F, Kobilay M, Madea B, Hoeft A, Stuber F (2007) Concentrations of tramadol and O-desmethyltramadol enantiomers in different CYP2D6 genotypes. Clin Pharmacol Ther 82:41–47

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