Enantioselective pharmacokinetics of tramadol in CYP2D6 extensive and poor metabolizers

Author:

Pedersen Rasmus Steen,Damkier Per,Brøsen Kim

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,General Medicine

Reference42 articles.

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2. Shipton EA (2000) Tramadol - present and future. Anaesth Intensive Care 28:363–374

3. Wu WN, Mckown LA, Liao S (2002) Metabolism of the analgesic drug ULTRAM (R) (tramadol hydrochloride) in humans: API-MS and MS/MS characterization of metabolites. Xenobiotica 32:411–425

4. Lintz W, Erlacin S, Frankus E, Uragg H (1981) Biotransformation of tramadol in man and animal. Arzneimittelforschung 31:1932–1943

5. Subrahmanyam V, Renwick AB, Walters DG, Young PJ, Price RJ, Tonelli AP et al (2001) Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes. Drug Metab Dispos 29:1146–1155

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