Treatment of Muscle Injuries with Platelet-Rich Plasma: a Review of the Literature

Author:

Setayesh Kian,Villarreal Arturo,Gottschalk Andrew,Tokish John M.,Choate W. Stephen

Publisher

Springer Science and Business Media LLC

Subject

Orthopedics and Sports Medicine

Reference46 articles.

1. • Rossi LA, Romoli ARM, Altieri BAB, Flor JAB, Scordo WE, Elizondo CM. Does Platelet-rich plasma decrease time to return to sports in acute muscle tear? A randomized controlled trial. Knee Surg Sports Traumatol Arthrosc. 2017;25:3319–25. The authors of this study looked to report the effects of autologous PRP injections and its effect on the return to play and recurrence rate after grade 2 muscle injuries in recreational and competitive athletes. Primary outcome was the mean return to play and secondary outcomes included changes in VAS scores as well as recurrence rate. A total of 75 patients were randomized into one of two groups: PRP injection with rehabilitation and rehabilitation alone. Excluding patients lost to follow-up, a total of 72 patients were included in the study; 34 in the treatment group and 38 in the control group. Mean time to play was 21.1 days for the PRP group and 25 days for the control group which they found to be significant. Subgroup analysis revealed there was no difference in return to play as far as muscle groups between hamstrings, gastrocnemius, and quadriceps. VAS scores were lower at all time points with the treatment group compared to controls. Additionally, two of the 35 initially treated in the PRP group had recurrence of muscle strain (5.7%) versus 4 of 40 in the control group (10%) but was not found to be statistically significant. This study ultimately showed that a single injection of autologous PRP with a rehabilitation program significantly shortened time to return to sports after and acute grade 2 muscle injury when compared with control group; however, the rate of recurrence was not significant between the two groups.

2. Connell DA, Schneider-Kolsky ME, Hoving JL, Malara F, Buchbinder R, Koulouris G, et al. Longitudinal study comparing sonographic and MRI assessments of acute and healing hamstring injuries. AJR Am J Roentgenol. 2004;183(4):975–84.

3. Ahmad CS, Redler LH, Ciccotti MG, Maffulli N, Longo UG, Bradley J. Evaluation and management of hamstring injuries. Am J Sports Med. 2013;41(12):2933–47.

4. Opar DA, Williams MD, Shield AJ. Hamstring strain injuries: factors that lead to injury and re-injury. Sports Med. 2012;42(3):209–26.

5. Woods C, Hawkins R, Hulse M, Hodson A. The football association medical research program: an audit of injuries in professional football-analysis of preseason injuries. Br J Sports Med. 2002;36(6):436–41.

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