Abstract
AbstractA catalytic diastereoselective Prins reaction for hydroxymethylation and hydroxylation of 1,3-diarylpropene was successfully utilized to prepare various 1,3-dioxanes 7 in 14–88% yields. Take advantage of the synthetic intermediate 7h, the key B/C rings in brazilin core could be constructed by the sequential of Friedel–Crafts/Ullmann-Ma rather than Ullmann-Ma/Friedel–Crafts reactions.
Graphical Abstract
Funder
National Natural Science Foundation of China
Scientific and Technological Project of Yunnan Precious Metals Laboratory
Yunnan Science and Technology Talent and Platform Program
Top Young Talent of Ten Thousand Talents Program of Yunnan Province
Start-up Fund of Yunnan University of Chinese Medicine
Bioactive Ethnopharmacol Molecules Chemical Conversion and Application Innovation Team of Department of Education of Yunnan Province
Publisher
Springer Science and Business Media LLC