Recombinant 3-Hydroxy 3-Methyl Glutaryl-CoA Reductase from Candida glabrata (Rec-CgHMGR) Obtained by Heterologous Expression, as a Novel Therapeutic Target Model for Testing Synthetic Drugs-Reference-Cited by-同舟云学术

Recombinant 3-Hydroxy 3-Methyl Glutaryl-CoA Reductase from Candida glabrata (Rec-CgHMGR) Obtained by Heterologous Expression, as a Novel Therapeutic Target Model for Testing Synthetic Drugs

Published:2017-01-30 Issue:4 Volume:182 Page:1478-1490
ISSN:0273-2289
Container-title:Applied Biochemistry and Biotechnology
language:en
Short-container-title:Appl Biochem Biotechnol

Author:

Andrade-Pavón Dulce,Cuevas-Hernández Roberto I.,Trujillo-Ferrara José G.,Hernández-Rodríguez César,Ibarra J. Antonio,Villa-Tanaca Lourdes^ORCID

Funder

CONACyT

SIP-IPN

Publisher

Springer Science and Business Media LLC

Subject

Molecular Biology,Applied Microbiology and Biotechnology,Biochemistry,General Medicine,Bioengineering,Biotechnology

Link

http://link.springer.com/article/10.1007/s12010-017-2412-9/fulltext.html

Reference52 articles.

1. Durr, I. F., & Rudney, H. (1960). The reduction of beta-hydroxy-beta-methyl-glutaryl coenzyme A to mevalonic acid. Journal of Biological Chemistry, 235, 2572–2578.

2. Burg, J. S., & Espenshade, P. J. (2011). Regulation of HMG-CoA reductase in mammals and yeast. Progress in Lipid Research, 50, 403–410.

3. Pichandi, S., Pasupathi, P., Raoc, Y. Y., Farook, J., Ambika, A., Ponnusha, B. S., Subramaniyam, S., Virumandy, R., & Subramaniyam, B. (2011). The role of statin drugs in combating cardiovascular diseases. International Journal of Current Science, 1, 47–56.

4. Aronow, W. S. (2015). Treatment of hypercholesterolemia in 2015. American Journal of Therapeutics. doi: 10.1097/MJT.0000000000000358 .

5. Westermayer, C., & Macreadie, I. G. (2007). Simvastatin reduces ergosterol levels, inhibits growth and causes loss of mtDNA in Candida glabrata. FEMS Yeast Research, 7, 436–441.

Cited by 13 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Inhibitors of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Decrease the Growth, Ergosterol Synthesis and Generation of petite Mutants in Candida glabrata and Candida albicans;International Journal of Molecular Sciences;2023-11-28

2. Pyrrole-Based Enaminones as Building Blocks for the Synthesis of Indolizines and Pyrrolo[1,2-a]pyrazines Showing Potent Antifungal Activity;Molecules;2023-10-23

3. Streptomyces albidoflavus Q antifungal metabolites inhibit the ergosterol biosynthesis pathway and yeast growth in fluconazole-resistant Candida glabrata : phylogenomic and metabolomic analyses;Microbiology Spectrum;2023-10-17

4. Calpain Regulates Reactive Oxygen Species Production during Capacitation through the Activation of NOX2 and NOX4;International Journal of Molecular Sciences;2023-02-16

5. Antifungal Activity of Fibrate-Based Compounds and Substituted Pyrroles That Inhibit the Enzyme 3-Hydroxy-methyl-glutaryl-CoA Reductase of Candida glabrata (CgHMGR), Thus Decreasing Yeast Viability and Ergosterol Synthesis;Microbiology Spectrum;2022-04-27