Antifungal Activity of Fibrate-Based Compounds and Substituted Pyrroles That Inhibit the Enzyme 3-Hydroxy-methyl-glutaryl-CoA Reductase of <i>Candida glabrata</i> (CgHMGR), Thus Decreasing Yeast Viability and Ergosterol Synthesis-Reference-Cited by-同舟云学术

Antifungal Activity of Fibrate-Based Compounds and Substituted Pyrroles That Inhibit the Enzyme 3-Hydroxy-methyl-glutaryl-CoA Reductase of Candida glabrata (CgHMGR), Thus Decreasing Yeast Viability and Ergosterol Synthesis

Published:2022-04-27 Issue:2 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Madrigal-Aguilar Damián A.¹^ORCID,Gonzalez-Silva Adilene²^ORCID,Rosales-Acosta Blanca²^ORCID,Bautista-Crescencio Celia²^ORCID,Ortiz-Álvarez Jossué²^ORCID,Escalante Carlos H.¹^ORCID,Sánchez-Navarrete Jaime³^ORCID,Hernández-Rodríguez César²^ORCID,Chamorro-Cevallos Germán⁴^ORCID,Tamariz Joaquín¹^ORCID,Villa-Tanaca Lourdes²^ORCID

Affiliation:

1. Departamento de Química Orgánica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico

2. Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico

3. Laboratorio de Investigación Microbiológica, Hospital Juárez de México, Mexico City, Mexico

4. Departamento de Farmacia, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico

Abstract

Within the context of the COVID-19 pandemic, there is currently an epidemiological alert in health care services due to outbreaks of Candida auris , Candida glabrata , and other fungal species multiresistant to conventional antifungals. Therefore, it is important to propose alternative molecular targets, as well as new antifungals.

Funder

Consejo Nacional de Ciencia y Tecnología

Instituto Politécnico Nacional

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01642-21

Reference35 articles.

1. Resistance of Candida to azoles and echinocandins worldwide

2. Fungal co-infection in COVID-19 patients: Should we be concerned?