Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models-Reference-Cited by-同舟云学术

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Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models

Published:2018-05-18 Issue:4 Volume:45 Page:621-635
ISSN:1567-567X
Container-title:Journal of Pharmacokinetics and Pharmacodynamics
language:en
Short-container-title:J Pharmacokinet Pharmacodyn

Author:

de Witte Wilhelmus E. A.,Rottschäfer Vivi,Danhof Meindert,van der Graaf Piet H.,Peletier Lambertus A.,de Lange Elizabeth C. M.

Funder

Innovative Medicines Initiative Joint Undertaking

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology

Link

http://link.springer.com/article/10.1007/s10928-018-9593-x/fulltext.html

Reference45 articles.

1. Copeland RA, Pompliano DL, Meek TD (2006) Drug-target residence time and its implications for lead optimization. Nat Rev Drug Discov 5:730–739. https://doi.org/10.1038/nrd2082

2. Lu H, Tonge PJ (2011) Drug-target residence time: critical information for lead optimization. Curr Opin Chem Biol 14:467–474. https://doi.org/10.1016/j.cbpa.2010.06.176.Drug-Target

3. Dahl G, Akerud T (2013) Pharmacokinetics and the drug-target residence time concept. Drug Discov Today 18:697–707

4. Schuetz DA, de Witte WEA, Wong YC, Knasmueller B, Richter L, Kokh DB, Sadiq SK, Bosma R, Nederpelt I, Heitman LH, Segala E, Amaral M, Guo D, Andres D, Georgi V, Stoddart LA, Hill S, Cooke RM, De Graaf C, Leurs R, Frech M, Wade RC, de Lange ECM, Ijzerman AP, Müller-Fahrnow A, Ecker GF (2017) Kinetics for drug discovery: an industry-driven effort to target drug residence time. Drug Discov Today 22:896–911. https://doi.org/10.1016/j.drudis.2017.02.002

5. de Witte WEA, Wong YC, Nederpelt I, Heitman LH, Danhof M, van der Graaf PH, Gilissen RA, de Lange EC (2016) Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in patients. Expert Opin Drug Discov 11:45–63. https://doi.org/10.1517/17460441.2016.1100163

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