Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in patients-Reference-Cited by-同舟云学术

Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in patients

Published:2015-10-20 Issue:1 Volume:11 Page:45-63
ISSN:1746-0441
Container-title:Expert Opinion on Drug Discovery
language:en
Short-container-title:Expert Opinion on Drug Discovery

Author:

de Witte Wilhelmus EA¹,Wong Yin Cheong¹,Nederpelt Indira²,Heitman Laura H²,Danhof Meindert¹,van der Graaf Piet H¹,Gilissen Ron AHJ³,de Lange Elizabeth C.M.¹

Affiliation:

1. Division of Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands

2. Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands

3. A Division of Janssen Pharmaceutica N.V., Janssen Research and Development, Turnhoutseweg 30, Beerse 2340, Belgium

Funder

Innovative Medicines Initiative Joint Undertaking

Publisher

Informa Healthcare

Subject

Drug Discovery

Link

https://www.tandfonline.com/doi/pdf/10.1517/17460441.2016.1100163

Reference113 articles.

1. Population Pharmacodynamic Modelling of Aspirin- and Ibuprofen-Induced Inhibition of Platelet Aggregation in Healthy Subjects

2. Comparative pharmacokinetic/pharmacodynamic analysis of proton pump inhibitors omeprazole, lansoprazole and pantoprazole, in humans

3. The dynamics of drug-target interactions: drug-target residence time and its impact on efficacy and safety

4. Residence Time of Receptor−Ligand Complexes and Its Effect on Biological Function

Cited by 28 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. High-throughput kinetics in drug discovery;SLAS Discovery;2024-07

2. Estimation of Drug-Target Residence Time by Targeted Molecular Dynamics Simulations;Journal of Chemical Information and Modeling;2022-11-09

3. Radiosynthesis and Preclinical Evaluation of an 18F-Labeled Triazolopyridopyrazine-Based Inhibitor for Neuroimaging of the Phosphodiesterase 2A (PDE2A);Pharmaceuticals;2022-10-15

4. Competition in drug binding and … the race to equilibrium;Fundamental & Clinical Pharmacology;2022-08-30

5. Current Approaches of Building Mechanistic Pharmacodynamic Drug–Target Binding Models;Methods in Molecular Biology;2021-12-10