Automated proper lumping for simplification of linear physiologically based pharmacokinetic systems

Author:

Pan Shan,Duffull Stephen B.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology

Reference22 articles.

1. Marieb EN (2012) Essentials of human anatomy & physiology. Person, Boston

2. van der Graaf PH, Benson N (2011) Systems pharmacology: bridging systems biology and pharmacokinetics–pharmacodynamics (PKPD) in drug discovery and development. Pharm Res 28:1460–1464

3. Lo A, Beh J, De Leon H, Hallow MK, Ramakrishna R, Rodrigo M, Sarkar A, Sarangapani R, Georgieva A (2011) Using a systems biology approach to explore hypotheses underlying clinical diversity of the renin angiotensin system and the response to antihypertensive therapies. Clinical trial simulations: applications and trends. Springer, New York

4. Nestorov I (2007) Whole-body physiologically based pharmacokinetic models. Expert Opin Drug Metab Toxicol 3:235–249

5. Tsamandouras N, Rostami-Hodjegan A, Aarons L (2015) Combining the ‘bottom up’ and ‘top down’ approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data. Br J Clin Pharmacol 79:48–55

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