Abstract
AbstractNowadays skin cancers have become a major area of concern because of the continuous exposure to sun rays (UV rays). Hence, the present work focused on the synthesis of an innovative 5-Fluorouracil (5-FU) microemulsion as a topical delivery system mainly used to treat various forms of skin cancer. The topical administration of most of the active compounds is impaired by limited skin permeability due to the presence of skin barriers. In this sequence, the microemulsion represents a cost-effective and convenient drug carrier system that successfully delivers the drug to and across the skin. Unfortunately, 5-FU reveals high toxicity and low tumor affinity became inefficient for patients with the risk of serious side effects. For decreasing of eluding some of its disadvantages we made it more effective by preparing its microemulsion with tween 80 (surfactant), isopropyl alcohol (co-surfactant), oleic acid (oil) in a four-component system. This study emphasized increasing the drug release by multiple times and a topical gel has been formulated and designs to elongate the drug release. All preparation of 5-FU microemulsion was characterized by physicochemical and drug release studies. The size of the 5-FU microemulsion was 550–600 nm confirmed by transmission electron microscopy (TEM) and Zetasizer. The clear microemulsion was prepared at pH 5–6. It shows viscosity in the limit of 13.52–18.23 Pa s. The outcome of the present work is satisfactory for skin cancer treatment.
Publisher
Springer Science and Business Media LLC
Subject
General Earth and Planetary Sciences,General Physics and Astronomy,General Engineering,General Environmental Science,General Materials Science,General Chemical Engineering
Reference37 articles.
1. Freeman RG, Knox JM, Heaton CL (1964) The treatment of skin cancer. A statistical study of 1,341 skin tumors comparing results obtained with irradiation, surgery, and curettage followed by electrodesiccation. Cancer 17(4):535–538
2. Scholz A (1997) History of skin cancer. In: Altmeyer P, Hoffmann K, Stücker M (eds) Skin cancer and UV radiation. Springer, Berlin
3. Recio A (2019) Tumour growth activation by the central nervous system—An integrative theory of cancer. Stress Health 35(4):569–581
4. Jones OT, Ranmuthu CKI, Hall PN, Funston G, Walter FM (2020) Recognising skin cancer in primary care. Adv Ther 37(1):603–616
5. Migden M (2020) Basal cell carcinoma - Advances in treatment and research. https://www.springer.com/gp/book/9783030268862. Accessed from 2020
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