Author:
Wong Eric T,Lok Edwin,Swanson Kenneth D.
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Oncology
Reference22 articles.
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3. Gera N, Yang A, Holtzman T, Lee SX, Wong ET, Swanson KD. Tumor treating fields perturb the localization of septins and cause aberrant mitotic exit. PLOS One (2015) doi: 10.1371/journal.pone.0125269 .This study demonstrated that septin 2, 6 and 7 complexes likely constitute the major intracellular target of TTFields. It also demonstrated that mitotic disruption occurred during anaphase and resulted in aberrant mitosis and subsequent p53 dependent cell cycle arrest and apoptosis suggesting a possible role for individual patient tumor genetics in TTFields response.
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