QT Interval Prolongation Associated With Cytotoxic and Targeted Cancer Therapeutics

Author:

Chandrasekhar Sanjay,Fradley Michael G.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Oncology

Reference156 articles.

1. Al-Khatib SM, LaPointe NMA, Kramer JM, Califf RM. What clinicians should know about the QT interval. JAMA. 2003;289(16):2120–7. https://doi.org/10.1001/jama.289.16.2120 .

2. Rautaharju PM, Surawicz B, Gettes LS, et al. AHA/ACCF/HRS recommendations for the standardization and interpretation of the electrocardiogram: part IV: the ST segment, T and U waves, and the QT interval: a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society: endorsed by the International Society for Computerized Electrocardiology. Circulation. 2009;119(10):e241–50. https://doi.org/10.1161/CIRCULATIONAHA.108.191096 .

3. Fradley MG, Moslehi J. QT prolongation and oncology drug development. Card Electrophysiol Clin. 2015;7(2):341–55. https://doi.org/10.1016/j.ccep.2015.03.013 .

4. Drew BJ, Ackerman MJ, Funk M, et al. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. Circulation. 2010;121(8):1047–60. https://doi.org/10.1161/CIRCULATIONAHA.109.192704 .

5. • Viskin S, Rosovski U, Sands AJ, et al. Inaccurate electrocardiographic interpretation of long QT: the majority of physicians cannot recognize a long QT when they see one. Heart Rhythm. 2005;2(6):569–74. https://doi.org/10.1016/j.hrthm.2005.02.011 Interesting study demonstrating the variability of different physicians’ abilities to accurately measure the QT interval, thereby underscoring the challenges inherent in QT interpretation.

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