Mechanisms, prevalence and management of cardiac arrhythmias in cancer patients: a comprehensive review

Author:

Flore Francesco1ORCID,Scacciavillani Roberto1,Iannaccone Giulia12ORCID,Narducci Maria Lucia2,Pinnacchio Gaetano2,Bencardino Gianluigi2,Perna Francesco2,Spera Francesco Raffaele3,Comerci Gianluca2,Camilli Massimiliano12ORCID,Lombardo Antonella12,Lanza Gaetano Antonio12,Crea Filippo12,Pelargonio Gemma12

Affiliation:

1. Department of Cardiovascular & Pulmonary Sciences, Catholic University of the Sacred Heart, 00168 Rome, Italy

2. Department of Cardiovascular Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy

3. Department of Cardiology, Sapienza Università di Roma, A.O. Sant'Andrea, 00198 Roma, Italy

Abstract

Recently, prognosis and survival of cancer patients has improved due to progression and refinement of cancer therapies; however, cardiovascular sequelae in this population augmented and now represent the second cause of death in oncological patients. Initially, the main issue was represented by heart failure and coronary artery disease, but a growing body of evidence has now shed light on the increased arrhythmic risk of this population, atrial fibrillation being the most frequently encountered. Awareness of arrhythmic complications of cancer and its treatments may help oncologists and cardiologists to develop targeted approaches for the management of arrhythmias in this population. In this review, we provide an updated overview of the mechanisms triggering cardiac arrhythmias in cancer patients, their prevalence and management.

Publisher

Future Medicine Ltd

Subject

Cardiology and Cardiovascular Medicine,Molecular Medicine

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