Metabolism and Action of 2′, 2′ -Difluorodeoxycytidine: Self-Potentiation of Cytotoxicity

Author:

Gandhi Varsha,Huang Peng,Xu Yi-Zheng,Heinemann Volker,Plunkett William

Publisher

Springer US

Reference11 articles.

1. Heinemann, V., Hertel, L.W., Grindey, G.B., and Plunkett, W. Comparison of the cellular pharmacokinetics and toxicity of 2′,2′-difluorodeoxycytidine and 1-β-D-arabinofuranosylcytosine. Cancer Res., 48:4024–4031, 1988.

2. Gandhi V. and Plunkett W. Modulatory activity of 2′,2′-difluorodeoxycytidine on the phosphorylation and cytotoxicity of arabinosyl nucleosides. Cancer Res., 50: 3675–3680, 1990.

3. Liliemark, J.O. and Plunkett, W. Regulation of 1-β-D-arabinofuranosylcytosine 5′-triphosphate accumulation in human leukemia cells by deoxycytidine 5′-triphosphate. Cancer Res., 46:1079–1083, 1986.

4. Huang, P., Chubb, S., Hertel, L.W., and Plunkett, W. Mechanism of action of 2′,2′-difluorodeoxycytidine triphosphate on DNA synthesis. Proc. Am. Assoc. Cancer Res., 31:426, 1990.

5. Heinemann, V., Hertel, L.W., Grindey, G.B., and Plunkett, W. Cellular elimination of 2′,2′-difluorodeoxycytidine 5′-triphosphate. Proc. Am. Assoc. Cancer Res., 29: 504, 1988.

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