Structure-Guided Synthesis and Mechanistic Studies Reveal Sweetspots on Naphthyl Salicyl Hydrazone Scaffold as Non-Nucleosidic Competitive, Reversible Inhibitors of Human Ribonucleotide Reductase

Author:

Huff Sarah E.1,Mohammed Faiz Ahmad2,Yang Mu1,Agrawal Prashansa1,Pink John3,Harris Michael E.4,Dealwis Chris G.25,Viswanathan Rajesh61ORCID

Affiliation:

1. Department of Chemistry, College of Arts and Sciences, Case Western Reserve University, Millis Science Center, Room 216, 2074 Adelbert Road, Cleveland, Ohio 44106, United States

2. Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, United States

3. Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, United States

4. Department of Chemistry, University of Florida, PO Box 117200, Gainseville, Florida 32611, United States

5. Center for Proteomics and the Department of Chemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, United States

6. Frank Hovorka Assistant Professor of Chemistry and Scientific Oversight Board Member−Small Molecule Drug Discovery Core, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, United States

Funder

National Cancer Institute

National Institute of General Medical Sciences

Department of Chemistry, Case Western Reserve University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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