A Phase I study of intravenous PI3K inhibitor copanlisib in Japanese patients with advanced or refractory solid tumors

Author:

Doi Toshihiko,Fuse Nozomu,Yoshino Takayuki,Kojima Takashi,Bando Hideaki,Miyamoto Hideaki,Kaneko Masato,Osada Motonobu,Ohtsu Atsushi

Funder

Bayer Yakuhin Ltd

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference24 articles.

1. Steelman LS, Stadelman KM, Chappell WH, Horn S, Bäsecke J, Cervello M, Nicoletti F, Libra M, Stivala F, Martelli AM, McCubrey JA (2008) Akt as a therapeutic target in cancer. Expert Opin Ther Targets 12:1139–1165

2. Liu P, Cheng H, Roberts TM, Zhao JJ (2009) Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov 8:627–644

3. Wong KK, Engelman JA, Cantley LC (2010) Targeting the PI3K signaling pathway in cancer. Curr Opin Genet Dev 20:87–90

4. Yuan TL, Cantley LC (2008) PI3K pathway alterations in cancer: variations on a theme. Oncogene 27:5497–5510

5. Haike K, Stasik E, Soujon M, Wengner AM, Petrova E, Genvresse I, Wilhelm S, Childs BH, Mumberg D, Liu N (2014) Molecular mechanisms supporting inhibition of PI3K isoforms by copanlisib in blocking B-cell signaling and tumor cell growth in diffuse large B-cell lymphoma. Poster 48 presented at the 1st American Society of Hematology Meeting on Lymphoma Biology, Colorado Springs, Colorado, USA

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