A comprehensive pharmacokinetic/pharmacodynamics analysis of the novel IGF1R/INSR inhibitor BI 893923 applying in vitro, in vivo and in silico modeling techniques-Reference-Cited by-同舟云学术

A comprehensive pharmacokinetic/pharmacodynamics analysis of the novel IGF1R/INSR inhibitor BI 893923 applying in vitro, in vivo and in silico modeling techniques

Published:2016-05-09 Issue:6 Volume:77 Page:1303-1314
ISSN:0344-5704
Container-title:Cancer Chemotherapy and Pharmacology
language:en
Short-container-title:Cancer Chemother Pharmacol

Author:

Titze Melanie I.,Schaaf Otmar,Hofmann Marco H.,Sanderson Michael P.,Zahn Stephan K.,Quant Jens,Lehr Thorsten

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Link

http://link.springer.com/content/pdf/10.1007/s00280-016-3049-z.pdf

Reference37 articles.

1. Pollak M (2012) The insulin and insulin-like growth factor receptor family in neoplasia: an update. Nat Rev Cancer 12:159–169. doi: 10.1038/nrc3215

2. Buck E, Mulvihill M (2011) Small molecule inhibitors of the IGF-1R/IR axis for the treatment of cancer. Expert Opin Investig Drugs 20:605–621. doi: 10.1517/13543784.2011.558501

3. De Meyts P, Palsgaard J, Sajid W, Theede A-M, Aladdin H (2002) Structural biology of insulin and IGF-1 receptors. Nat Rev Drug Discov 1:769–783. doi: 10.1038/nrd917

4. Belfiore A, Malaguarnera R (2011) Insulin receptor and cancer. Endocr Relat Cancer 18:R125–R147. doi: 10.1530/ERC-11-0074

5. King H, Aleksic T, Haluska P, Macaulay VM (2014) Can we unlock the potential of IGF-1R inhibition in cancer therapy? Cancer Treat Rev 40:1096–1105. doi: 10.1016/j.ctrv.2014.07.004

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