An allometric pharmacokinetic/pharmacodynamics model for BI 893923, a novel IGF-1 receptor inhibitor-Reference-Cited by-同舟云学术

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An allometric pharmacokinetic/pharmacodynamics model for BI 893923, a novel IGF-1 receptor inhibitor

Published:2017-02-27 Issue:3 Volume:79 Page:545-558
ISSN:0344-5704
Container-title:Cancer Chemotherapy and Pharmacology
language:en
Short-container-title:Cancer Chemother Pharmacol

Author:

Titze Melanie I.,Schaaf Otmar,Hofmann Marco H.,Sanderson Michael P.,Zahn Stephan K.,Quant Jens,Lehr Thorsten

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Link

http://link.springer.com/content/pdf/10.1007/s00280-017-3252-6.pdf

Reference37 articles.

1. Hewish M, Chau I, Cunningham D (2009) Insulin-like growth factor 1 receptor targeted therapeutics: novel compounds and novel treatment strategies for cancer medicine. Recent Pat Anticancer Drug Discov 4:54–72. doi: 10.2174/157489209787002515

2. Buck E, Mulvihill M (2011) Small molecule inhibitors of the IGF-1R/IR axis for the treatment of cancer. Expert Opin Investig Drugs 20:605–621. doi: 10.1517/13543784.2011.558501

3. De Meyts P, Palsgaard J, Sajid W, Theede A-M, Aladdin H (2002) Structural biology of insulin and IGF-1 receptors. Nat Rev Drug Discov 1:769–783. doi: 10.1038/nrd917

4. Louvi A, Accili D, Efstratiadis A (1997) Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development. Dev Biol 189:33–48. doi: 10.1006/dbio.1997.8666

5. Pollak M (2012) The insulin and insulin-like growth factor receptor family in neoplasia: an update. Nat Rev Cancer 12:159–169. doi: 10.1038/nrc3215

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