Camptothecin analogs with enhanced activity against human breast cancer cells. I. Correlation of potency with lipophilicity and persistence in the cleavage complex

Author:

Adams David J.,Silva Mateus Webba da,Flowers James L.,Kohlhagen Glenda,Pommier Yves,Colvin O. Michael.,Manikumar Govindarajan,Wani Mansukh C.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference28 articles.

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3. Flowers JL, Ludeman SM, Gamcsik MP, Colvin OM, Shao KL, Boal JH, Springer JB, Adams DJ (2000) Evidence for a role of chloroethylaziridine in the cytotoxicity of cyclophosphamide. Cancer Chemother Pharmacol 45:335–344

4. Gamcsik M, Kasibhatla M, Adams D, Flowers J, Colvin O, Manikumar G, Wani M, Wall M, Kohlhagen G, Pommier Y (2001) Dual role of glutathione in modulating camptothecin activity: depletion potentiates activity, but conjugation enhances the stability of the topoisomerase I-DNA cleavage complex. Mol Cancer Ther 1:11–20

5. Giovanella B, Stehlin J, Wall M, Wani M, Nicholas A, Liu L, Silber R, Potmesil M (1989) DNA topoisomerase I-targeted chemotherapy of human colon cancer in xenografts. Science 246:1046–1048

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