The Novel Silatecan 7-tert-Butyldimethylsilyl-10-hydroxycamptothecin Displays High Lipophilicity, Improved Human Blood Stability, and Potent Anticancer Activity-Reference-Cited by-同舟云学术

The Novel Silatecan 7-tert-Butyldimethylsilyl-10-hydroxycamptothecin Displays High Lipophilicity, Improved Human Blood Stability, and Potent Anticancer Activity

Published:2000-09-19 Issue:21 Volume:43 Page:3970-3980
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bom David¹,Curran Dennis P.¹,Kruszewski Stefan¹,Zimmer Stephen G.¹,Thompson Strode J.¹,Kohlhagen Glenda¹,Du Wu¹,Chavan Ashok J.¹,Fraley Kimberly A.¹,Bingcang Alex L.¹,Latus Lori J.¹,Pommier Yves¹,Burke Thomas G.¹

Affiliation:

1. Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Pharmaceutics Sciences, College of Pharmacy, Department of Microbiology and Immunology, College of Medicine, and Experimental Therapeutics Program, Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40506; Molecular Pharmacology Program, National Cancer Institute, Bethesda, Maryland 20892; and Tigen Pharmaceuticals, Inc., Lexington, Kentucky 40506

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm000144o

Reference34 articles.

1. The Current Status of Camptothecin Analogues as Antitumor Agents

2. The S-phase cytotoxicity of camptothecin

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