The Novel Silatecan 7-tert-Butyldimethylsilyl-10-hydroxycamptothecin Displays High Lipophilicity, Improved Human Blood Stability, and Potent Anticancer Activity

Author:

Bom David1,Curran Dennis P.1,Kruszewski Stefan1,Zimmer Stephen G.1,Thompson Strode J.1,Kohlhagen Glenda1,Du Wu1,Chavan Ashok J.1,Fraley Kimberly A.1,Bingcang Alex L.1,Latus Lori J.1,Pommier Yves1,Burke Thomas G.1

Affiliation:

1. Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260; Division of Pharmaceutics Sciences, College of Pharmacy, Department of Microbiology and Immunology, College of Medicine, and Experimental Therapeutics Program, Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40506; Molecular Pharmacology Program, National Cancer Institute, Bethesda, Maryland 20892; and Tigen Pharmaceuticals, Inc., Lexington, Kentucky 40506

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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