A phase I/II study of fixed-dose-rate gemcitabine and S-1 with concurrent radiotherapy for locally advanced pancreatic cancer

Author:

Goji Takahiro,Kimura Tetsuo,Miyamoto Hiroshi,Takehara Masanori,Kagemoto Kaizo,Okada Yasuyuki,Okazaki Jun,Takaoka Yoshifumi,Miyamoto Yoshihiko,Mitsui Yasuhiro,Matsumoto Sayo,Sueuchi Tatsuhisa,Tanaka Kumiko,Fujino Yasuteru,Takaoka Toshi,Kitamura Shinji,Okamoto Koichi,Kimura Masako,Sogabe Masahiro,Muguruma Naoki,Okahisa Toshiya,Sato Yasuhiro,Sagawa Tamotsu,Fujikawa Koji,Sato Yasushi,Ikushima Hitoshi,Takayama Tetsuji

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference19 articles.

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2. Yeo TP, Hruban RH, Leach SD, Wilentz RE, Sohn TA, Kern SE, Iacobuzio-Donahue CA, Maitra A, Goggins M, Canto MI, Abrams RA, Laheru D, Jaffee EM, Hidalgo M, Yeo CJ (2002) Pancreatic cancer. Curr Probl Cancer 26(4):176–275

3. Moertel CG, Frytak S, Hahn RG, O’Connell MJ, Reitemeier RJ, Rubin J, Schutt AJ, Weiland LH, Childs DS, Holbrook MA, Lavin PT, Livstone E, Spiro H, Knowlton A, Kalser M, Barkin J, Lessner H, Mann-Kaplan R, Ramming K, Douglas HO, Thomas P, Nave H, Bateman J, Lokich J, Brooks J, Chaffey J, Corson JM, Zamcheck N, Novak JW (1981) Therapy of locally unresectable pancreatic carcinoma: a randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5-fluorouracil), and high dose radiation + 5-fluorouracil: the Gastrointestinal Tumor Study Group. Cancer 48(8):1705–1710

4. Sultana A, Tudur Smith C, Cunningham D, Starling N, Tait D, Neoptolemos JP, Ghaneh P (2007) Systematic review, including meta-analyses, on the management of locally advanced pancreatic cancer using radiation/combined modality therapy. Br J Cancer 96(8):1183–1190. doi: 10.1038/sj.bjc.6603719

5. Wolff RA, Evans DB, Gravel DM, Lenzi R, Pisters PW, Lee JE, Janjan NA, Charnsangavej C, Abbruzzese JL (2001) Phase I trial of gemcitabine combined with radiation for the treatment of locally advanced pancreatic adenocarcinoma. Clin Cancer Res 7(8):2246–2253

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