A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells-Reference-Cited by-同舟云学术

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells

Published:2009-12-13 Issue:3 Volume:66 Page:535-545
ISSN:0344-5704
Container-title:Cancer Chemotherapy and Pharmacology
language:en
Short-container-title:Cancer Chemother Pharmacol

Author:

Massey Andrew J.,Williamson Douglas S.,Browne Helen,Murray James B.,Dokurno Pawel,Shaw Terry,Macias Alba T.,Daniels Zoe,Geoffroy Stephanie,Dopson Melanie,Lavan Paul,Matassova Natalia,Francis Geraint L.,Graham Christopher J.,Parsons Rachel,Wang Yikang,Padfield Antony,Comer Mike,Drysdale Martin J.,Wood Mike

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Link

http://link.springer.com/content/pdf/10.1007/s00280-009-1194-3.pdf

Reference43 articles.

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2. Nollen EA, Morimoto RI (2002) Chaperoning signaling pathways: molecular chaperones as stress-sensing ‘heat shock’ proteins. J Cell Sci 115(Pt 14):2809–2816

3. Young JC, Agashe VR, Siegers K, Hartl FU (2004) Pathways of chaperone-mediated protein folding in the cytosol. Nat Rev Mol Cell Biol 5(10):781–791

4. Daugaard M, Rohde M, Jaattela M (2007) The heat shock protein 70 family: highly homologous proteins with overlapping and distinct functions. FEBS Lett 581(19):3702–3710

5. Young JC, Barral JM, Ulrich HF (2003) More than folding: localized functions of cytosolic chaperones. Trends Biochem Sci 28(10):541–547

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