A phase 1 and pharmacodynamic study of chronically-dosed, single-agent veliparib (ABT-888) in patients with BRCA1- or BRCA2-mutated cancer or platinum-refractory ovarian or triple-negative breast cancer

Author:

Manzo Julia,Puhalla Shannon,Pahuja Shalu,Ding Fei,Lin Yan,Appleman Leonard,Tawbi Hussein,Stoller Ronald,Lee James J.,Diergaarde Brenda,Kiesel Brian F.,Yu Jing,Tan Antoinette R.,Belani Chandra P.,Chew Helen,Garcia Agustin A.,Morgan Robert J.,Wahner Hendrickson Andrea E.,Visscher Daniel W.,Hurley Rachel M.,Kaufmann Scott H.,Swisher Elizabeth M.,Oesterreich Steffi,Katz Tiffany,Ji Jiuping,Zhang Yiping,Parchment Ralph E.,Chen Alice,Duan Wenrui,Giranda Vincent,Shepherd Stacie P.,Ivy S. Percy,Chu Edward,Beumer Jan H.ORCID,

Funder

National Cancer Institute

National Institutes of Health

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference62 articles.

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2. Berti M, Ray Chaudhuri A, Thangavel S, Gomathinayagam S, Kenig S, Vujanovic M, Odreman F, Glatter T, Graziano S, Mendoza-Maldonado R, Marino F, Lucic B, Biasin V, Gstaiger M, Aebersold R, Sidorova JM, Monnat RJ Jr, Lopes M, Vindigni A (2013) Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition. Nat Struct Mol Biol 20(3):347–354. https://doi.org/10.1038/nsmb.2501

3. Ray Chaudhuri A, Callen E, Ding X, Gogola E, Duarte AA, Lee JE, Wong N, Lafarga V, Calvo JA, Panzarino NJ, John S, Day A, Crespo AV, Shen B, Starnes LM, de Ruiter JR, Daniel JA, Konstantinopoulos PA, Cortez D, Cantor SB, Fernandez-Capetillo O, Ge K, Jonkers J, Rottenberg S, Sharan SK, Nussenzweig A (2016) Replication fork stability confers chemoresistance in BRCA-deficient cells. Nature 535(7612):382–387. https://doi.org/10.1038/nature18325

4. Bryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E, Kyle S, Meuth M, Curtin NJ, Helleday T (2005) Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 434(7035):913–917. https://doi.org/10.1038/nature03443

5. Farmer H, McCabe N, Lord CJ, Tutt AN, Johnson DA, Richardson TB, Santarosa M, Dillon KJ, Hickson I, Knights C, Martin NM, Jackson SP, Smith GC, Ashworth A (2005) Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434(7035):917–921. https://doi.org/10.1038/nature03445

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