Affiliation:
1. grid.452574.5 0000000417971452 Brazilian Bioethanol Science and Technology Laboratory, CTBE/CNPEM P.O. Box 6070 CEP 13083-970 Campinas SP Brazil
2. grid.411237.2 0000000121887235 Department of Chemical Engineering and Food Engineering Federal University of Santa Catarina (UFSC) P.O. Box 476 CEP 88040-900 Florianópolis SC Brazil
Abstract
Abstract
This article gives an overview of high-cell-density cultures for polyhydroxyalkanoate (PHA) production and their modes of operation for increasing productivity. High cell densities are very important in PHA production mainly because this polymer is an intracellular product accumulated in various microorganisms, so a high cellular content is needed for the polymer production. This review describes relevant results from fed-batch, repeated batch, and continuous modes of operation without and with cell recycle for the production of these polymers by microorganisms. Finally, recombinant microorganisms for PHA production, as well future directions for PHA production, are discussed.
Publisher
Oxford University Press (OUP)
Subject
Applied Microbiology and Biotechnology,Biotechnology,Bioengineering
Cited by
73 articles.
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