Affiliation:
1. Corteva ® Agriscience 3100 James Savage Rd 48642 Midland MI USA
2. grid.508744.a 0000 0004 7642 3544 Corteva Agriscience 901 Loveridge Rd 94565 Pittsburg CA USA
3. Bioprocess Mixing Solutions, LLC 6228 Deerwood Ct Greenwood IN USA
4. grid.508744.a 0000 0004 7642 3544 Corteva Agriscience 9330 Zionsville Rd Indianapolis IN USA
Abstract
Abstract
Different methods are used at Corteva® Agriscience to improve our understanding of mixing in large-scale mechanically agitated fermentors. These include (a) use of classical empirical correlations, (b) use of small-scale models, and (c) computational fluid dynamics (CFD). Each of these approaches has its own inherent strengths and limitations. Classic empirical or semi-empirical correlations can provide insights into mass transfer, blending, shear, and other important factors but are dependent on the geometry and condition used to develop the correlations. Laboratory-scale modelling can be very useful to study mixing and model the effect of heterogeneity on the culture, but success is highly dependent on the methodology applied. CFD provides an effective means to accelerate the exploration of alternative design strategies through physics-based computer simulations that may not be adequately described by existing knowledge or correlations. However, considerable time and effort is needed to build and validate these models. In this paper, we review the various approaches used at Corteva Agriscience to deepen our understanding of mixing in large-scale fermentation processes.
Publisher
Oxford University Press (OUP)
Subject
Applied Microbiology and Biotechnology,Biotechnology,Bioengineering
Cited by
8 articles.
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