Synthesis, characterization, and in vitro evaluation of the selective P2Y2 receptor antagonist AR-C118925-Reference-Cited by-同舟云学术

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Synthesis, characterization, and in vitro evaluation of the selective P2Y2 receptor antagonist AR-C118925

Published:2016-10-20 Issue:1 Volume:13 Page:89-103
ISSN:1573-9538
Container-title:Purinergic Signalling
language:en
Short-container-title:Purinergic Signalling

Author:

Rafehi Muhammad,Burbiel Joachim C.,Attah Isaac Y.,Abdelrahman Aliaa,Müller Christa E.

Funder

State of North-Rhine Westfalia, Germany

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Cellular and Molecular Neuroscience,Molecular Biology

Link

http://link.springer.com/content/pdf/10.1007/s11302-016-9542-3.pdf

Reference43 articles.

1. Abbracchio MP, Burnstock G, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, Knight GE, Fumagalli M, Gachet C, Jacobson KA, Weisman GA (2006) International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev 58:281–341

2. Lustig KD, Shiau AK, Brake AJ, Julius D (1993) Expression cloning of an ATP receptor from mouse neuroblastoma cells. Proc Natl Acad Sci U S A 90:5113–5117

3. Murthy KS, Makhlouf GM (1998) Coexpression of ligand-gated P2X and G protein-coupled P2Y receptors in smooth muscle. Preferential activation of P2Y receptors coupled to phospholipase C (PLC)-beta1 via Galphaq/11 and to PLC-beta3 via Gbetagammai3. J Biol Chem 273:4695–4704

4. Bagchi S, Liao Z, Gonzalez FA, Chorna NE, Seye CI, Weisman GA, Erb L (2005) The P2Y2 nucleotide receptor interacts with alphav integrins to activate go and induce cell migration. J Biol Chem 280:39050–39057

5. Liao Z, Seye CI, Weisman GA, Erb L (2007) The P2Y2 nucleotide receptor requires interaction with alpha v integrins to access and activate G12. J Cell Sci 120:1654–1662

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