Genetic Mechanisms Highlight Shared Pathways for the Pathogenesis of Polygenic Type 1 Diabetes and Monogenic Autoimmune Diabetes

Author:

Johnson Matthew B.,Cerosaletti Karen,Flanagan Sarah E.,Buckner Jane H.

Funder

National Institutes of Health

Wellcome Trust

Publisher

Springer Science and Business Media LLC

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Reference85 articles.

1. Bottazzo GF, Florin-Christensen A, Doniach D. Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet (London, England) [Internet]. 1974 Nov 30 [cited 2019 Jan 4];2(7892):1279–83. Available from: http://www.ncbi.nlm.nih.gov/pubmed/4139522

2. •• Onengut-Gumuscu S, Chen W-M, Burren O, Cooper NJ, Quinlan AR, Mychaleckyj JC, et al. Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers. Nat Genet [Internet]. 2015 Apr 9 [cited 2019 Jan 4];47(4):381–6. Available from: http://www.nature.com/articles/ng.3245 . Fine-mapped susceptibility loci in T1D and showed that T1D was more genetically similar to antibody-driven autoimmune diseases than non-antibody-associated.

3. Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, et al. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet [Internet]. 2009 Jun 10 [cited 2019 Jan 4];41(6):703–7. Available from: http://www.nature.com/articles/ng.381

4. Andlauer TFM, Buck D, Antony G, Bayas A, Bechmann L, Berthele A, et al. Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation. Sci Adv [Internet]. 2016 Jun [cited 2019 Jan 30];2(6):e1501678. Available from: https://doi.org/10.1126/sciadv.1501678

5. Erlich H, Valdes AM, Noble J, Carlson JA, Varney M, Concannon P, et al. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes [Internet]. 2008 Apr 1 [cited 2019 Jan 8];57(4):1084–92. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18252895

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