Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation

Author:

Andlauer Till F. M.12ORCID,Buck Dorothea3,Antony Gisela4ORCID,Bayas Antonios5,Bechmann Lukas67,Berthele Achim3,Chan Andrew89,Gasperi Christiane3,Gold Ralf8,Graetz Christiane10,Haas Jürgen11,Hecker Michael12,Infante-Duarte Carmen13,Knop Matthias1,Kümpfel Tania14,Limmroth Volker15,Linker Ralf A.16,Loleit Verena3,Luessi Felix10,Meuth Sven G.17,Mühlau Mark23,Nischwitz Sandra1,Paul Friedemann13,Pütz Michael18,Ruck Tobias17,Salmen Anke89,Stangel Martin19,Stellmann Jan-Patrick20ORCID,Stürner Klarissa H.20ORCID,Tackenberg Björn18,Then Bergh Florian21,Tumani Hayrettin2223,Warnke Clemens24,Weber Frank125,Wiendl Heinz17,Wildemann Brigitte11,Zettl Uwe K.12,Ziemann Ulf26ORCID,Zipp Frauke10,Arloth Janine127,Weber Peter1,Radivojkov-Blagojevic Milena28ORCID,Scheinhardt Markus O.29,Dankowski Theresa29,Bettecken Thomas1,Lichtner Peter2830,Czamara Darina1,Carrillo-Roa Tania1,Binder Elisabeth B.131,Berger Klaus32,Bertram Lars3334,Franke Andre35,Gieger Christian3637,Herms Stefan3839ORCID,Homuth Georg40ORCID,Ising Marcus1,Jöckel Karl-Heinz41,Kacprowski Tim40ORCID,Kloiber Stefan1,Laudes Matthias42,Lieb Wolfgang43,Lill Christina M.1033,Lucae Susanne1,Meitinger Thomas2830,Moebus Susanne41,Müller-Nurasyid Martina444546,Nöthen Markus M.38,Petersmann Astrid47,Rawal Rajesh3637ORCID,Schminke Ulf48,Strauch Konstantin4449,Völzke Henry50,Waldenberger Melanie3637,Wellmann Jürgen32,Porcu Eleonora51,Mulas Antonella5152,Pitzalis Maristella51,Sidore Carlo51ORCID,Zara Ilenia53,Cucca Francesco5152,Zoledziewska Magdalena5152ORCID,Ziegler Andreas295455,Hemmer Bernhard23,Müller-Myhsok Bertram1256

Affiliation:

1. Max Planck Institute of Psychiatry, 80804 Munich, Germany.

2. Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.

3. Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany.

4. Central Information Office KKNMS, Philipps University Marburg, 35043 Marburg, Germany.

5. Department of Neurology, Klinikum Augsburg, 86156 Augsburg, Germany.

6. Department of Neurology, University of Leipzig, 04103 Leipzig, Germany.

7. Institute of Medical Microbiology, Otto-von-Guericke University, 39120 Magdeburg, Germany.

8. Department of Neurology, St. Josef Hospital, Ruhr-University Bochum, 44791 Bochum, Germany.

9. Department of Neurology, University Hospital Bern and University of Bern, 3010 Bern, Switzerland.

10. Department of Neurology, Focus Program Translational Neurosciences (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.

11. Department of Neurology, University Hospital Heidelberg, 69120 Heidelberg, Germany.

12. Department of Neurology, University of Rostock, 18147 Rostock, Germany.

13. NeuroCure Clinical Research Center, Department of Neurology, and Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine, and Charité University Medicine Berlin, 10117 Berlin, Germany.

14. Institute of Clinical Neuroimmunology, Ludwigs-Maximilians-Universität, 81377 Munich, Germany.

15. Department of Neurology, Hospital Köln-Merheim, 51109 Köln, Germany.

16. Department of Neurology, University Hospital Erlangen, 91054 Erlangen, Germany.

17. Department of Neurology, Klinik für Allgemeine Neurologie, University of Münster, 48149 Münster, Germany.

18. Clinical Neuroimmunology Group, Department of Neurology, Philipps-University of Marburg, 35043 Marburg, Germany.

19. Department of Neurology, Hannover Medical School, 30625 Hannover, Germany.

20. Institute of Neuroimmunology and Multiple Sclerosis and Department of Neurology, University Medical Centre Hamburg-Eppendorf, 20251 Hamburg, Germany.

21. Department of Neurology and Translational Center for Regenerative Medicine, University of Leipzig, 04103 Leipzig, Germany.

22. Department of Neurology, University of Ulm, 89081 Ulm, Germany.

23. Neurological Clinic Dietenbronn, 88477 Schwendi, Germany.

24. Department of Neurology, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany.

25. Neurological Clinic, Medical Park, 65520 Bad Camberg, Germany.

26. Department of Neurology and Stroke, and Hertie Institute for Clinical Brain Research, Eberhard-Karls-Universität Tübingen, 72076 Tübingen, Germany.

27. Institute of Computational Biology, Helmholtz Zentrum München, 85764 Neuherberg, Germany.

28. Institute of Human Genetics, Helmholtz Zentrum München, 85764 Neuherberg, Germany.

29. Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, 23562 Lübeck, Germany.

30. Institute of Human Genetics, Technische Universität München, 81675 Munich, Germany.

31. Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30329, USA.

32. Institut für Epidemiologie und Sozialmedizin der Universität Münster, 48149 Münster, Germany.

33. Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Integrative and Experimental Genomics, University of Lübeck, 23562 Lübeck, Germany.

34. School of Public Health, Faculty of Medicine, Imperial College London, SW7 2AZ London, UK.

35. Institute of Clinical Molecular Biology, Kiel University, 24105 Kiel, Germany.

36. Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, 85764 Neuherberg, Germany.

37. Institute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany.

38. Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany.

39. Department of Biomedicine, Division of Medical Genetics, University of Basel, 4031 Basel, Switzerland.

40. Interfaculty Institute for Genetics and Functional Genomics, Ernst Moritz Arndt University and University Medicine Greifswald, 17475 Greifswald, Germany.

41. Institute of Medical Informatics, Biometry, and Epidemiology, University Hospital Essen, University Duisburg-Essen, 45122 Essen, Germany.

42. Department I of Internal Medicine, Kiel University, 24105 Kiel, Germany.

43. Institute of Epidemiology and Biobank popgen, Kiel University, 24105 Kiel, Germany.

44. Institute of Genetic Epidemiology, Helmholtz Zentrum München, 85764 Neuherberg, Germany.

45. Department of Medicine I, Ludwig-Maximilians-Universität, 81377 Munich, Germany.

46. DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, 80802 Munich, Germany.

47. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.

48. Department of Neurology, University Medicine Greifswald, 17475 Greifswald, Germany.

49. Institute of Medical Informatics, Biometry, and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, 81377 Munich, Germany.

50. Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.

51. Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, 09042 Cagliari, Italy.

52. Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, 07100 Sassari, Italy.

53. Center for Advanced Studies, Research and Development in Sardinia (CRS4), Pula, 09010 Cagliari, Italy.

54. Zentrum für Klinische Studien, Universität zu Lübeck, 23562 Lübeck, Germany.

55. School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, Scottsville 3209, South Africa.

56. Institute of Translational Medicine, University of Liverpool, Liverpool L69 3BX, UK.

Abstract

Genome-wide study in Germans identifies four novel multiple sclerosis risk genes and confirms already known gene loci.

Funder

Bundesministerium für Bildung und Forschung

Munich Cluster for Systems Neurology

Deutsche Forschungsgemeinschaft

Wellcome Trust

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Cited by 124 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3