Loss of silencing activity caused by 5′-terminal modification with d-/l-isonucleotide (isoNA) or locked nucleic acid (LNA) could not be restored by 5′-terminal phosphorylation-Reference-Cited by-同舟云学术

Loss of silencing activity caused by 5′-terminal modification with d-/l-isonucleotide (isoNA) or locked nucleic acid (LNA) could not be restored by 5′-terminal phosphorylation

Published:2013-12-19 Issue:2 Volume:57 Page:329-334
ISSN:1674-7291
Container-title:Science China Chemistry
language:en
Short-container-title:Sci. China Chem.

Author:

Huang Ye,Chen Zhuo,Wang Zhuo,Li YaTing,Chen Yue,Yang ZhenJun,Zhang LiHe

Publisher

Springer Science and Business Media LLC

Subject

General Chemistry

Link

http://link.springer.com/content/pdf/10.1007/s11426-013-5032-4.pdf

Reference21 articles.

1. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in caenorhabditis elegans. Nature, 1998, 391(6669): 806–811

2. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature, 2001, 411(6836): 494–498

3. Weitzer S, Martinez J. The human RNA kinase hclp1 is active on 3′ transfer RNA exons and short interfering RNAs. Nature, 2007, 447(7141): 222–226

4. Kaya E, Doudna JA. Biochemistry. Guided tour to the heart of RISC. Science, 2012, 336(6084): 985–986

5. Lima WF, Wu H, Nichols JG, Sun H, Murray HM, Crooke ST. Binding and cleavage specificities of human argonaute 2. J Biol Chem, 2009, 284(38): 26017–26028

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Isonucleotide incorporation into middle and terminal siRNA duplexes exhibits high gene silencing efficacy and nuclease resistance;Organic & Biomolecular Chemistry;2017

2. Spatial conservation studies of nucleobases in 10–23 DNAzyme by 2′-positioned isonucleotides and enantiomers for increased activity;Organic & Biomolecular Chemistry;2016

3. Simultaneous extraction of DNA and RNA from Escherichia coli BL 21 based on silica-coated magnetic nanoparticles;Science China Chemistry;2015-09-17