Spatial conservation studies of nucleobases in 10–23 DNAzyme by 2′-positioned isonucleotides and enantiomers for increased activity-Reference-Cited by-同舟云学术

Spatial conservation studies of nucleobases in 10–23 DNAzyme by 2′-positioned isonucleotides and enantiomers for increased activity

Author:

Yang Xiantao¹²³⁴⁵,Xiao Zhangping¹²³⁴⁵,Zhu Junfei⁶⁷⁸⁵,Li Zhiwen⁶⁷⁸⁵,He Junlin⁹¹⁰⁵,Zhang Lihe¹²³⁴⁵,Yang Zhenjun¹²³⁴⁵

Affiliation:

1. State Key Laboratory of Natural and Biomimetic Drugs

2. School of Pharmaceutical Sciences

3. Peking University

4. Beijing

5. China

6. College of Life Sciences

7. Guizhou University

8. Guiyang 550025

9. Beijing Institute of Pharmacology and Toxicology

10. Beijing 100850

Abstract

d-/l-Isonucleotides were used to modify the catalytic core and recognition arms of 10–23 DNAzyme and prominently improved its bioactivity.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

Reference45 articles.

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