Acetaminophen as a Cosubstrate and Inhibitor of Prostaglandin H Synthase

Author:

Harvison Peter J.,Egan R. W.,Gale P. H.,Nelson Sidney D.

Publisher

Springer US

Reference24 articles.

1. Andersson, B., Nordenskjöld, M., Rahimtula, A., and Moldeus, P., 1982, Prostaglandin synthetase-catalyzed activation of phenacetin metabolites to genotoxic products, Mol. Pharmacol., 22: 479.

2. Boyd, J. A., and Eling, T. E., 1981, Prostaglandin endoperoxide synthetasedependent cooxidation of acetaminophen to intermediates which covalently bind in vitro to rabbit renal medullary microsomes, J. Pharmacol. Exp. Ther., 219: 659.

3. Dahlin, D. C., and Nelson, S. D., 1982, Synthesis, decomposition kinetics, and preliminary toxicological studies of pure N-acetyl-p-benzoquinone imine, a proposed toxic metabolite of acetaminophen, J. Med. Chem., 25: 885.

4. Egan, R. W., Paxton, J., and Kuehl, F. A., Jr., 1976, Mechanism for irreversible self-deactivation of prostaglandin synthetase, J. Biol. Chem., 251: 7329.

5. Egan, R. W., Gale, P. H., Beveridge, G. C., Marnett, L. J., and Kuehl, F. A., Jr., 1980, Direct and indirect involvement of radical scavengers during prostaglandin biosynthesis, in: “Advances in Prostaglandin andThromboxane Research, Vol. 6,” B. Samuelson, P. W. Ramwell, and R. Paoletti, eds., Raven Press, New York, p. 153.

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