N-methyl-2-pyridone-5-carboxamide (N-Me-2PY) has potent anti-fibrotic and anti-inflammatory activity in a fibrotic kidney model: is it an old uremic toxin?
Author:
Funder
Shionogi
Publisher
Springer Science and Business Media LLC
Subject
Physiology (medical),Nephrology,Physiology
Link
https://link.springer.com/content/pdf/10.1007/s10157-023-02379-1.pdf
Reference28 articles.
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2. Ruiz-Ortega M, Lamas S, Ortiz A. Antifibrotic agents for the management of CKD: a review. Am J Kidney Dis. 2022;80:251–63.
3. Vanholder R, Glorieux G, De Smet R, et al. New insights in uremic toxins. Kidney Int. 2003;63:S6–10.
4. Vanholder R, Schepers E, Pletinck A, et al. The uremic toxicity of indoxyl sulfate and p-cresyl sulfate: a systematic review. J Am Soc Nephrol. 2014;25:1897–907.
5. Vanholder R, De Smet R. Pathophysiologic effects of uremic retention solutes. J Am Soc Nephrol. 1999;10:1815–23.
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