Co-localization of islet amyloid polypeptide and insulin in the B cell secretory granules of the human pancreatic islets

Author:

Lukinius A.,Wilander E.,Westermark G. T.,Engstr�m U.,Westermark P.

Publisher

Springer Science and Business Media LLC

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Reference31 articles.

1. Westermark P, Wernstedt C, Wilander E, Sletten K (1986) A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas. Biochem Biophys Res Commun 140: 827?831

2. Westermark P, Wernstedt C, Wilander E, Hayden D, O'Brien T, Johnson K (1987) Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptidelike protein also present in normal islet cells. Proc Natl Acad Sci USA 84: 3881?3885

3. Westermark P, Wernstedt C, O'Brian TD, Hayden DW, Johnson KH (1987) Islet amyloid in type 2 human diabetes mellitus and adult diabetic cats contains a novel putative polypeptide hormone. Am J Pathol 127: 414?417

4. Cooper GJS, Willis AC, Clark A, Turner RC, Sim RB, Reid KBM (1987) Purification and characterization of a peptide from amyloid-rich pancreases of Type 2 diabetic patients. Proc Natl Acad Sci USA 84: 8628?8632

5. Johnson KH, O'Brian TD, Hayden DW, Jordan K, Ghobrial HKG, Mahoney WC, Westermark P (1988) Immunolocalization of islet amyloid polypeptide (IAPP) in pancreatic beta cells by means of peroxidase-antiperoxidase (PAP) and protein A-gold techniques. Am J Pathol 130: 1?8

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