Genetic factors underlying gluten-sensitive enteropathy
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pulmonary and Respiratory Medicine,Immunology and Allergy,Immunology
Link
http://link.springer.com/content/pdf/10.1007/s11882-001-0061-z.pdf
Reference74 articles.
1. Csizmadia CG, Mearin ML, von Blomberg BM, et al.: An iceberg of childhood coeliac disease in the Netherlands [letter]. Lancet 1999, 353:813–814.Gluten-sensitive enteropathy is frequently unrecognized and screening studies have shown a prevalence of one in 300 to one in 100 in the general population. The prevalence of unrecognized GSE in young children in the Netherlands was found to be one in 198.
2. Rostami K, Kerckhaert J, Tiemessen R, et al.: Sensitivity of antiendomysium and antigliadin antibodies in untreated celiac disease: disappointing in clinical practice. Am J Gastroenterol 1999, 94(4):888–894.This study showed that the specificity and positive predictive value of endomysial antibody (EMA) for celiac disease was excellent. The sensitivity of EMA, however, differed between celiac disease subgroups; in patients with total villous atrophy, the sensitivity of EMA was 100% (17/17). However, in patients with partial villous atrophy, the sensitivity of EMA was disappointing, only 31% (9/29).
3. Hovdenak N, Hovlid E, Aksnes L, et al.: High prevalence of asymptomatic coeliac disease in Norway: a study of blood donors. Eur J Gastroenterol Hepatol 1999, 11(2):185–187.The study indicates a prevalence of one in 340 among asymptomatic and presumably healthy people.
4. Ivarsson A, Persson LA, Juto P, et al.: High prevalence of undiagnosed coeliac disease in adults: a Swedish populationbased study. J Intern Med 1999, 245(1):63–68.Celiac disease was confirmed by intestinal biopsy showing enteropathy in 10 individuals (seven women and three men), corresponding to a prevalence of 5.3 per 1000 (95% CI = 2.5–9.7). The majority of cases (eight out of ten) had not been diagnosed prior to the screening, although many had symptoms compatible with celiac disease.
5. Korponay-Szabo IR, Kovacs JB, Czinner A, et al.: High prevalence of silent celiac disease in preschool children screened with IgA/IgG antiendomysium antibodies. J Pediatr Gastroenterol Nutr 1999, 28(1):26–30.
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