Potentiation of 6-mercaptopurine after time and dose-dependent pretreatment with methotrexate in malignant human T- and B-lymphoblasts

Author:

Bökkerink Jos P. M.,De Abreu Ronney A.,Bakker Marinka A. H.,Hulscher Tilly W.

Publisher

Springer Netherlands

Reference10 articles.

1. Becher H, Weber M, Lohr GW: Purine nucleotide synthesis in normal and leukemic blood cells. Klin Wschr 56: 275–283, 1978.

2. Bökkerink JPM, bakker MAH, Hulscher MW, De Abreu RA, Laarhoven JPRM van, Schretlen EDAM, De Bruyn CHMM: Sequence, time and dose dependent synergism of methotrexate and 6-mercaptopurine in malignant human T-lymphoblasts. Submitted for publication.

3. Buesa-Perez JM, Leyva A, Pinedo HM: Effect of methotrexate on 5-phosphoribosyl 1-pyrophosphate levels in LI210 leukemia cells in vitro. Cancer Res 40: 139–144, 1980.

4. Craft AW, Rankin A, Aherne W: Methotrexate absorption in children with acute lymphoblastic leukemia. Cancer Treat Rep 65 (Suppl. 1): 77–81, 1981.

5. Frei E III, Freireich EJ, Gehan E, Pinkel D, Holland JF, Selawry O, Haurani F, Spurr CL, Hayes DM, James GW, Rothberg H, Sodee DB, Rundles RW, Schroeder LR, Hoogstraten B, Wolman IJ, Traggis DG, Cooper T, Gendel BR, Ebaugh F, Taylor R: From the acute Leukemia Group B. Studies of sequential and combination antimetabolite therapy in acute leukemia: 6-mercaptopurine and methotrexate. Blood 18: 431–454, 1961.

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