Energy and caloric restriction, and fasting and cancer: a narrative review
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Published:2020-11-14
Issue:5
Volume:29
Page:2299-2304
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ISSN:0941-4355
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Container-title:Supportive Care in Cancer
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language:en
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Short-container-title:Support Care Cancer
Author:
Ibrahim Ezzeldin M., Al-Foheidi Meteb H., Al-Mansour Mubarak M.ORCID
Abstract
AbstractDietary interventions have a significant impact on body metabolism. The sensitivity of cancer cells to nutrient and energy deficiency is an evolving characteristic of cancer biology. Preclinical studies provided robust evidence that energy and caloric restrictions could hinder both cancer growth and progression, besides enhancing the efficacy of chemotherapy and radiation therapy. Moreover, several, albeit low-powered, clinical trials have demonstrated clinical benefits in cancer patients. Future research will inform and firmly establish the potential efficacy and safety of these dietary interventions. Here, we review the current evidence and ongoing research investigating the relationship between various dietary restriction approaches and cancer outcomes.
Publisher
Springer Science and Business Media LLC
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