Comparison of the Pharmacokinetics of RIPK1 Inhibitor GSK2982772 in Healthy Western and Japanese Subjects
Author:
Funder
GlaxoSmithKline
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Pharmacology
Link
http://link.springer.com/content/pdf/10.1007/s13318-020-00652-2.pdf
Reference19 articles.
1. Weisel K, Scott NE, Tompson DJ, Votta BJ, Madhavan S, Povey K, et al. Randomized clinical study of safety, pharmacokinetics, and pharmacodynamics of RIPK1 inhibitor GSK2982772 in healthy volunteers. Pharmacol Res Perspect. 2017. https://doi.org/10.1002/prp2.365.
2. Zhou W, Yuan J. Necroptosis in health and diseases. Semin Cell Dev Biol. 2014;35:14–23.
3. Kopalli SR, Kang T-B, Koppula S. Necroptosis inhibitors as therapeutic targets in inflammation mediated disorders—a review of the current literature and patents. Expert Opin Ther Patents. 2016;26(11):1239–56.
4. Weisel K, Berger S, Papp K, Maari C, Krueger J, et al. Response to inhibition of receptor-interacting protein kinase 1 (RIPK1) in active psoriasis: a randomized placebo-controlled study. J Clin Pharmacol Ther; 2020. https://doi.org/10.1002/cpt.1852.
5. Mao J, Martin I, McLeod J, Nolan G, van Horn R, et al. Perspective: 4beta-hydroxycholesterol as an emerging endogenous biomarker of hepatic CYP3A. Drug Metab Rev. 2017;49(1):18–34.
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