Randomized clinical study of safety, pharmacokinetics, and pharmacodynamics of RIPK1 inhibitor GSK2982772 in healthy volunteers
Author:
Affiliation:
1. GlaxoSmithKline; Collegeville PA USA
2. GlaxoSmithKline; Stevenage UK
3. GlaxoSmithKline; Cambridge UK
Funder
GlaxoSmithKline
Publisher
Wiley
Subject
General Pharmacology, Toxicology and Pharmaceutics,Neurology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/prp2.365/fullpdf
Reference12 articles.
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2. Necroptosis in health and diseases;Zhou;Semin Cell Dev Biol,2014
3. Necroptosis inhibitors as therapeutic targets in inflammation mediated disorders - a review of the current literature and patents;Kopalli;Expert Opin Ther Pat,2016
4. RIP kinases: key decision makers in cell death and innate immunity;Humphries;Cell Death Differ,2015
5. Identification of RIP1 kinase as a specific cellular target of necrostatins;Degterev;Nat Chem Biol,2008
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